EndothelinB-mediated apoptosis of A375 melanoma cells

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Endothelin-induced apoptosis of A375 human melanoma cells.

Endothelin-1 (ET-1) inhibited serum-dependent growth of asynchronized A375 human melanoma cells, and the growth inhibitory effect was markedly enhanced when ET-1 was applied to the cells synchronized at G1/S boundary by double thymidine blocks. Flow cytometric analysis revealed that ET-1 did not inhibit the cell cycle progression after the release of the block but caused a significant increase ...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1998

ISSN: 0021-5198

DOI: 10.1016/s0021-5198(19)40521-0